IMMUNOHISTOCHEMICAL LOCALIZATION OF THE NEURON-SPECIFIC GLUCOSE-TRANSPORTER (GLUT3) TO NEUROPIL IN ADULT-RAT BRAIN

The precise histologic localization of GLUT3, a glucose transporter th ought to be restricted to neurons, is unknown. Using a high-affinity, specific antiserum against rodent GLUT3 for immunocytochemistry, light microscopic staining concentrates heterogeneously in the neuropil in a region- and lamina-specific manner; intense staining characterizes a reas with high rates of glucose utilization such as inferior colliculu s and pyriform cortex. Neuropil localization with little perikaryal st aining suggests that GLUT3 may provide the energy needed locally for s ynaptic transmission.