TREATMENT OF 42 CASES OF CANINE LYMPHOSARCOMA WITH COMBINATION CHEMOTHERAPY - 1987-1993

Forty-two dogs with lymphosarcoma (excluding primary skin or neurologi cal forms) were treated with a combination chemotherapy protocol conta ining vincristine, L-asparaginase, cyclophosphamide, doxorubicin, chlo rambucil, methotrexate and prednisolone. Thirty-six dogs (86%) achieve d complete remission with a median remission time of 6.25 months. Dogs that achieved complete remission had a 27% chance of maintaining remi ssion for 12 months or more and a 40% chance of survival for 12 months or more. The median survival time for dogs that achieved complete rem ission was 8.125 months but only 1.65 months for dogs in which only pa rtial response to treatment occurred. Sixty percent of dogs experience d no or only minor side effects, 21% experienced side effects on one o ccasion that required therapeutic intervention and 19% of dogs were as sessed as having serious side effects.