A STUDY OF THE EFFECT OF SPECIFIC GROWTH-RATE AND ACETATE ON RECOMBINANT PROTEIN-PRODUCTION OF ESCHERICHIA-COLI JM107

Authors
TURNER C GREGORY ME TURNER MK
Citation
C. Turner et al., A STUDY OF THE EFFECT OF SPECIFIC GROWTH-RATE AND ACETATE ON RECOMBINANT PROTEIN-PRODUCTION OF ESCHERICHIA-COLI JM107, Biotechnology letters, 16(9), 1994, pp. 891-896
Citations number
17
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
16
Issue
9
Year of publication
1994
Pages
891 - 896
Database
ISI
SICI code
0141-5492(1994)16:9<891:ASOTEO>2.0.ZU;2-K
Abstract
The growth of Escherichia coli in fed-batch and continuous culture is examined and results show that cl-amylase production is strongly depen dent on specific growth rate (dilution rate) of the culture and produc tion is greatest at an intermediate rate. Using continuous culture, it has also been found that the presence of acetate above a certain conc entration reduces both mu(max), and the production of recombinant prot ein.