DYNAMIC TRANSITION OF ALPHA-HELIX TO BETA-SHEET STRUCTURE IN LINEAR SURFACTIN CORRELATING TO CRITICAL MICELLE CONCENTRATION

Authors
OSMAN M ISHIGAMI Y ISHIKAWA K ISHIZUKA Y HOLMSEN H
Citation
M. Osman et al., DYNAMIC TRANSITION OF ALPHA-HELIX TO BETA-SHEET STRUCTURE IN LINEAR SURFACTIN CORRELATING TO CRITICAL MICELLE CONCENTRATION, Biotechnology letters, 16(9), 1994, pp. 913-918
Citations number
21
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
16
Issue
9
Year of publication
1994
Pages
913 - 918
Database
ISI
SICI code
0141-5492(1994)16:9<913:DTOATB>2.0.ZU;2-5
Abstract
Linear heptapeptide surfactin was prepared by alkaline cleavage of the lactone ring of cyclic surfactin. The structure of linear surfactin w as characterised and confirmed by FAB-mass-spectroscopy, FT-IR and HPL C analysis. It was found that linear surfactin easily forms micelles i n aqueous solutions by coordinating beta-sheet formation from alpha-he lical monomolecules, and the cmc value found to be 1.28x10(5) M. The C D spectra indicates conformational change of linear surfactin from alp ha-helical below cme to beta-sheet above cmc.