Im. Elhassan et al., EVIDENCE OF ENDOTHELIAL INFLAMMATION, T-CELL ACTIVATION, AND T-CELL REALLOCATION IN UNCOMPLICATED PLASMODIUM-FALCIPARUM MALARIA, The American journal of tropical medicine and hygiene, 51(3), 1994, pp. 372-379
Citations number
40
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
To explain the observation that acute Plasmodium falciparum malaria is
associated with a transient inability of peripheral blood cells to re
spond to antigenic stimulation in vitro, we have postulated the diseas
e-induced reallocation of peripheral lymphocytes, possibly by adhesion
to inflamed endothelium. We measured plasma levels of soluble markers
of endothelial inflammation and T cell activation in 32 patients suff
ering from acute, uncomplicated P. falciparum malaria. as well as in 1
0 healthy, aparasitemic control donors. All donors were residents of a
malaria-endemic area of Eastern State Sudan. In addition, we measured
the T cell surface expression of the interleukin-2 receptor (CD25) an
d the lymphocyte function-associated antigen (LFA-1; CD11a/CD18). We f
ound that the plasma levels of all inflammation and activation markers
were significantly increased in the malaria patients compared with th
e control donors. In addition, we found a disease-induced depletion of
T cells with high expression of the LFA-1 antigen, particularly in th
e CD4(+) subset. The results obtained provide further support for the
hypothesis of T cell reallocation to inflamed endothelium in acute P.
falciparum malaria.