EXPERIMENTAL-EVIDENCE FOR TOXIC DAMAGE-INDUCED BY A DIMERIC ANTHRACENONE - DIAST T-514 (PEROXISOMICINE A(2))

Dimeric anthracenones obtained from the genus Karwinskia (Rhamnaceae) are characteristic compounds isolated from the plants of this species. Previous toxicity studies demonstrated Diast T-514 to be toxic to ani mals in experimental settings. Diast T-514 extracted and characterized from Karwinskia parvifolia, was studied in CD1 mice. The LD(50) for t his compound was determined. Animals were tested with Diast T-514 foll owing enteral and parenteral administration. An LD(50) dose by both or al and intraperitoneal administration showed selective damage to targe t organs. (C) 1997 Elsevier Science Ireland Ltd.