Ideally, one might wish to reverse the burden of proof in the regulati
on of chemical substances, so that a substance is regarded as hazardou
s unless proven non-hazardous. Due to the structure of toxicological k
nowledge, a full reversal is not practicable. Nevertheless, important
steps in the direction of a reversal are both possible and desirable.
(C) 1997 Elsevier Science Ireland Ltd.