EVALUATION OF FREQUENCIES OF POLYMORPHIC ALLELES OF LOCUS DXS52 OF THE HUMAN X-CHROMOSOME IN THE MOSCOW POPULATION

The frequency of different polymorphic variants of the multiallelic lo cus DXS52 (St14) of the human X-chromosome, adjacent to the factor VII I gene, was evaluated by means of PCR for the heterogeneous population of Moscow and Moscow oblast'. It was shown that the heterozygosity in dex of this polymorphism in the studied population is much lower (0,71 ) than in Western Europe (0.80 - 0.85), which can apparently be explai ned by higher frequency of the prevailing allele 1690 (0.52 compared t o 0.36). Five new St14 alleles were detected during this study. The to tal informativity of the polymorphic markers St14 and Hind III (intron 19 of the factor VIII gene), which are most commonly used for hemophi lia A detection, was evaluated. Among 83 investigated women, only 57 ( 69%) were heterozygous for at least one of the markers used, which is also much lower than in Western-European populations (90 - 95%).