Ab. Fontaine et al., STENT-INDUCED INTIMAL HYPERPLASIA - ARE THERE FUNDAMENTAL DIFFERENCESBETWEEN FLEXIBLE AND RIGID STENT DESIGNS, Journal of vascular and interventional radiology, 5(5), 1994, pp. 739-744
PURPOSE: To evaluate possible differences in neointimal development re
sulting from overdilation of rigid versus flexible vascular stents. MA
TERIALS AND METHODS: Twelve vascular sheaths were placed bilaterally t
hrough femoral arteries in six swine. After angiographic measurement,
12 stents (six flexible and six rigid) were balloon expanded to 8-mm d
iameters in 12 6-mm iliac arteries (approximately 30% overdilation). A
ll stents were similar in surface area, gauge, and type of wire (tanta
lum). The primary difference was longitudinal flexibility (low hoop st
rength) versus rigidity (high hoop strength). Stents were studied with
angiography and intravascular ultrasound 5 weeks after implantation.
The animals were killed, and the stented segments were removed and exa
mined histologically. RESULTS: Rigid stents maintained larger diameter
s than flexible stents: mean, 6.52 mm versus 5.82 mm (mean difference,
0.70; standard deviation [SD], 0.47; confidence interval [CI], +/- 0.
49; P < .05). In addition, rigid stents developed a thicker, eccentric
neointimal reaction relative to flexible stents: mean 1.08 mm versus
0.74 mm (mean difference, 0.338; SD, 0.315; CI, +/- 0.331; P < .05). C
ONCLUSION: Rigid stents maintain larger diameters over the long term r
elative to flexible stents when overdilated in normal swine arteries.
However, a thicker neointima develops within the lumen of rigid stents
at follow-up (greater late loss).