INTERACTION OF THE PROTEIN-KINASE RAF-1 WITH 14-3-3-PROTEINS

Authors
FU H XIA K PALLAS DC CUI C CONROY K NARSIMHAN RP MAMON H COLLIER RJ ROBERTS TM
Citation
H. Fu et al., INTERACTION OF THE PROTEIN-KINASE RAF-1 WITH 14-3-3-PROTEINS, Science, 266(5182), 1994, pp. 126-129
Citations number
26
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
266
Issue
5182
Year of publication
1994
Pages
126 - 129
Database
ISI
SICI code
0036-8075(1994)266:5182<126:IOTPRW>2.0.ZU;2-M
Abstract
Members of a family of highly conserved proteins, termed 14-3-3 protei ns, were found by several experimental approaches to associate with Ra f-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Ra f-1. The association of 14-3-3 proteins and Raf-1 was not substantiall y affected by the activation state of Raf.