SEX DETERMINATION

Authors
HAWKINS JR
Citation
Jr. Hawkins, SEX DETERMINATION, Human molecular genetics, 3, 1994, pp. 1463-1467
Citations number
54
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
Human molecular genetics → ACNP
ISSN journal
09646906
Volume
3
Year of publication
1994
Pages
1463 - 1467
Database
ISI
SICI code
0964-6906(1994)3:<1463:SD>2.0.ZU;2-R
Abstract
The cloning of the 'testis determining gene', SRY, promised a revoluti on in the understanding of sex determination in humans. The failure to isolate further genes involved in sex determination has been a disapp ointment. The biology of SRY, however, has kept the field exciting. Th e discoveries of sex reversing SRY mutations with variable penetrance, but with full expressivity, rapid SRY sequence evolution and circular Sry transcripts could not have been predicted.