A ROLE FOR THE CYTOPLASMIC TAIL OF THE BETA-CHAIN OF CD8 IN THYMIC SELECTION

Citation
A. Itano et al., A ROLE FOR THE CYTOPLASMIC TAIL OF THE BETA-CHAIN OF CD8 IN THYMIC SELECTION, Immunity, 1(4), 1994, pp. 287-290
Citations number
20
Categorie Soggetti
Immunology
Journal title
ISSN journal
10747613
Volume
1
Issue
4
Year of publication
1994
Pages
287 - 290
Database
ISI
SICI code
1074-7613(1994)1:4<287:ARFTCT>2.0.ZU;2-1
Abstract
The CD8 coreceptor plays a critical role in the recognition of foreign antigens by mature T cells and in the development of class I-restrict ed T cells. CD8 can be expressed on the surface of T cells as either a heterodimer composed of an alpha and beta chain, or as a homodimer co mposed of two alpha chains. In this report, we show that a CD8 beta tr ansgene that lacks a cytoplasmic domain can suppress expression of wil d-type endogenous CD8 beta and act as a dominant negative mutation. We show that this dominant negative CD8 beta transgene interferes with t he development of mature CD8 T cells to different extents depending on the individual class I-restricted TCR. These data suggest CD8 beta pl ays a role in thymic development, and that different class I-restricte d TCRs differ in their dependence on the cytoplasmic tail of CD8 beta.