CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF THE FAB FRAGMENT OFA HUMAN MONOCLONAL IGM RHEUMATOID-FACTOR (2A2)

Authors
SOHI MK SUTTON BJ CORPER AL WAN T MAINI RN BROWN C RIJNDERS T BEALE D FEINSTEIN A HUMPHREYS AS TAUSSIG MJ
Citation
Mk. Sohi et al., CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF THE FAB FRAGMENT OFA HUMAN MONOCLONAL IGM RHEUMATOID-FACTOR (2A2), Journal of Molecular Biology, 242(5), 1994, pp. 706-708
Citations number
18
Categorie Soggetti
Biology
Journal title
Journal of Molecular Biology → ACNP
ISSN journal
00222836
Volume
242
Issue
5
Year of publication
1994
Pages
706 - 708
Database
ISI
SICI code
0022-2836(1994)242:5<706:CAPAOT>2.0.ZU;2-N
Abstract
Crystals of the Fab fragment of a human monoclonal IgM rheumatoid fact or have been obtained and are suitable for X-ray structure determinati on. This molecule, derived from the synovial B cells of a patient with rheumatoid arthritis, is an autoantibody with specificity for IgG Fc. The crystals have space group P2(1), cell dimensions a = 69.0 Angstro m, b = 76.6 Angstrom, c = 98.8 Angstrom and beta = 90.6 degrees, and d iffract to a resolution of at least 2.8 Angstrom.