F. Guerrera et al., SYNTHESIS OF SUBSTITUTED [1]BENZOTHIENO[2,3-B]PYRAZINES AND THEIR ABILITY TO ANTAGONIZE KCL INDUCED CONTRACTIONS, Il Farmaco, 49(7-8), 1994, pp. 467-473
A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally
related to caroverine, was synthesized. Some of these compounds showed
an appreciable inhibition towards KCl induced contractions on isolate
d rat aortic rings, and a lower potency towards negative inotropic act
ivity tested on isolated guinea pig atrium.