SYNTHESIS OF SUBSTITUTED [1]BENZOTHIENO[2,3-B]PYRAZINES AND THEIR ABILITY TO ANTAGONIZE KCL INDUCED CONTRACTIONS

Authors
GUERRERA F SALERNO L SARVA MC SIRACUSA MA RESCIFINA A SCALIA R BIANCHI A
Citation
F. Guerrera et al., SYNTHESIS OF SUBSTITUTED [1]BENZOTHIENO[2,3-B]PYRAZINES AND THEIR ABILITY TO ANTAGONIZE KCL INDUCED CONTRACTIONS, Il Farmaco, 49(7-8), 1994, pp. 467-473
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
7-8
Year of publication
1994
Pages
467 - 473
Database
ISI
SICI code
0014-827X(1994)49:7-8<467:SOS[AT>2.0.ZU;2-6
Abstract
A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolate d rat aortic rings, and a lower potency towards negative inotropic act ivity tested on isolated guinea pig atrium.