3-ALPHA-HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY OF SOME 4-CARBOXYPYRAZOL-5-YL)-1,2,3-BENZOTRIAZIN-4(3H)ONE AND QUINAZOLIN-4(3H)-ONE ACIDS

Authors
PLESCIA S RAFFA D DAIDONE G SCHILLACI D MAGGIO B
Citation
S. Plescia et al., 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY OF SOME 4-CARBOXYPYRAZOL-5-YL)-1,2,3-BENZOTRIAZIN-4(3H)ONE AND QUINAZOLIN-4(3H)-ONE ACIDS, Il Farmaco, 49(7-8), 1994, pp. 505-507
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
7-8
Year of publication
1994
Pages
505 - 507
Database
ISI
SICI code
0014-827X(1994)49:7-8<505:3DIAOS>2.0.ZU;2-F
Abstract
Some carboxylic acids of N(3)-pyrazole substituted 1,2,3-benzotriazin- 4-(3H)-ones and- quinazolin-4-(3H)-ones were prepared and tested for t he inhibitory property of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol. The results indicated that the degree of inhibition can be used to predict the antiinflammatory potency of the compounds desc ribed.