EFFECT OF SITE-SPECIFIC MODIFICATION ON RESTRICTION ENDONUCLEASES ANDDNA MODIFICATION METHYLTRANSFERASES

Restriction endonucleases have site-specific interactions with DNA tha t can often be inhibited by site-specific DNA methylation and other si te-specific DNA modifications. However, such inhibition cannot general ly be predicted. The empirically acquired data on these effects are ta bulated for over 320 restriction endonucleases. In addition, a table o f known site-specific DNA modification methyltransferases and their sp ecificities is presented along with EMBL database accession numbers fo r cloned genes.