RELATIONSHIP BETWEEN PLASMA AND BONE CONCENTRATIONS OF CEFUROXIME ANDFLUCLOXACILLIN

(i) The objective was to determine the range of bone levels of cefurox ime and flucloxacillin achieved after one intravenous (IV) administrat ion of different dosages of cefuroxime and flucloxacillin. (ii) Six gr oups of five patients participated in the study. The first three group s (A-C) received respectively 1500 mg, 1000 mg, and 500 mg cefuroxime intravenously and the second three groups (D-F) received 2000 mg, 1500 mg, and 1000 mg flucloxacillin intravenously. (iii) Parenteral admini stration of cefuroxime and flucloxacillin resulted in measurable bone concentrations in all patients. (iv) Large inter-individual variation in bone concentration was observed. (v) The bone concentrations of IV cefuroxime were higher (1500 mg, p=0.0057; 1000 mg, p=0.0260) than tho se of flucloxacillin. The bone concentrations of cefuroxime and fluclo xacillin were dose dependent.