PHARMACOKINETIC PROFILE OF CONJUGATED VERRUCAROL URINARY METABOLITES IN DOGS

The pharmacokinetics and renal excretion of a trichothecene mycotoxin, verrucarol, were studied in six mongrel dogs following IV administrat ion (0.4 mg kg(-1)). The fraction of verrucarol excreted intact in the urine ranged from 0.9% to 2.7% of the administered dose. The fraction of verrucarol metabolites excreted in the urine was 32-60% for verruc aryl glucuronides and 32-47% for verrucaryl sulphates. These urinary c onjugated metabolites were analysed quantitatively following their enz ymatic hydrolysis. The half-life of verrucarol calculated from the uri nary data of its conjugated metabolites was not significantly differen t from the half-life calculated from the plasma data of the parent com pound.