INHIBITORY EFFECT OF TOPICAL APPLICATION OF POLYMERIZED FERULIC ACID,A SYNTHETIC LIGNIN, ON TUMOR PROMOTION IN MOUSE SKIN 2-STAGE TUMORIGENESIS

Authors
ASANOMA M TAKAHASHI K MIYABE M YAMAMOTO K YOSHIMI N MORI H KAWAZOE Y
Citation
M. Asanoma et al., INHIBITORY EFFECT OF TOPICAL APPLICATION OF POLYMERIZED FERULIC ACID,A SYNTHETIC LIGNIN, ON TUMOR PROMOTION IN MOUSE SKIN 2-STAGE TUMORIGENESIS, Carcinogenesis, 15(9), 1994, pp. 2069-2071
Citations number
35
Categorie Soggetti
Oncology
Journal title
Carcinogenesis → ACNP
ISSN journal
01433334
Volume
15
Issue
9
Year of publication
1994
Pages
2069 - 2071
Database
ISI
SICI code
0143-3334(1994)15:9<2069:IEOTAO>2.0.ZU;2-I
Abstract
A dehydrogenation polymer of ferulic acid (DHP-FA), a synthetic lignin , was evaluated for its ability to inhibit tumor promotion by 12-O-tet radecanoylphorbol-13-acetate (TPA) in the 7,12-dimethylbenz[a]anthrace ne-treated skin of female ICR mice. Topical application of DHP-FA inhi bits TPA-induced tumor promotion, whereas a monomeric ferulic acid doe s not show the inhibitory effect.