Bs. Levine et al., EFFECT OF CALCIUM CITRATE SUPPLEMENTATION ON URINARY CALCIUM-OXALATE SATURATION IN FEMALE STONE FORMERS - IMPLICATIONS FOR PREVENTION OF OSTEOPOROSIS, The American journal of clinical nutrition, 60(4), 1994, pp. 592-596
In 14 women aged 37-68 y with a history of renal calcium calculi, bone
densities were 12.0% below those of age-matched control subjects at t
he L2-4 lumbar spine (P = 0.007) and 6.4% less at the femoral neck (P
= 0.095). A low-oxalate diet was supplemented with 1 g Ca/d as citrate
. In 6 mo, plasma 1,25(OH)(2)D concentrations fell from 53.2 +/- 18.8
to 41.9 +/- 15.2 ng/L (P = 0.02) and parathyroid hormone from 39.1 +/-
17.0 to 30.8 +/- 12.5 ng/L (P = 0.02). Calcium oxalate saturation was
2.15 +/- 1.38 at baseline, 2.27 +/- 1.00 at 1 mo, and 2.06 +/- 1.57 a
t 6 mo. The increase in urinary calcium at 1 mo from 4.411 +/- 1.87 to
6.514 +/- 2.82 mmol/24 h (P = 0.01) was offset by a parallel increase
in citrate excretion from 2.909 +/- 1.45 to 3.455 +/- 1.34 mmol/24 h
(P = 0.03). Calcium citrate supplementation did not increase the litho
genicity of the women in this protocol.