STRONG IGG ISOTYPIC ANTIBODY-RESPONSE IN SOWDAH TYPE ONCHOCERCIASIS

Citation
Nw. Brattig et al., STRONG IGG ISOTYPIC ANTIBODY-RESPONSE IN SOWDAH TYPE ONCHOCERCIASIS, The Journal of infectious diseases, 170(4), 1994, pp. 955-961
Citations number
35
Categorie Soggetti
Infectious Diseases
ISSN journal
00221899
Volume
170
Issue
4
Year of publication
1994
Pages
955 - 961
Database
ISI
SICI code
0022-1899(1994)170:4<955:SIIAIS>2.0.ZU;2-1
Abstract
Persons exposed to Onchocerca volvulus express differences in manifest ations of onchocerciasis ranging from hyporeactive (generalized) to hy perreactive (sowdah) forms; absence of disease is seen in endemic norm al persons. Analysis of the IgG isotypic antibody response to O. volvu lus extracts and nonparasite ubiquitous antigens in 92 West Africans r evealed highest anti-O. volvulus IgG1 and IgG2 responses in sowdah, hi gh levels in the generalized form, and low antibody levels in endemic normal persons. Nonexposed persons had no antibodies. A significant Ig G3 antibody response was detected only in sowdah, while high IgG4 leve ls occurred in both polar groups but were absent in both control group s. Isotypic responses to antigens unrelated to O. volvulus were simila r in all groups but showed higher IgG1 and IgG2 levels in sowdah. Sowd ah patients had high levels of Ro/SS-A antibodies, circulating immune complexes, and eosinophil cationic protein. These results document a s trong B cell response in African sowdah and indicate variations in imm une responsiveness.