THE CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES .13. THE OXIDATIONOF 10-DEACETYLBACCATIN-III

Authors
APPENDINO G FENOGLIO I CRAVOTTO G VARESE M GARIBOLDI P GABETTA B
Citation
G. Appendino et al., THE CHEMISTRY AND OCCURRENCE OF TAXANE DERIVATIVES .13. THE OXIDATIONOF 10-DEACETYLBACCATIN-III, Gazzetta chimica italiana, 124(6), 1994, pp. 253-257
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Gazzetta chimica italiana → ACNP
ISSN journal
00165603
Volume
124
Issue
6
Year of publication
1994
Pages
253 - 257
Database
ISI
SICI code
0016-5603(1994)124:6<253:TCAOOT>2.0.ZU;2-L
Abstract
The three secondary hydroxyls of 10-deacetylbaccatin III, 1, can be se lectively oxidized. However, only the 13-dehydro derivative is stable under the reaction conditions, whereas the 10- and the 7- dehydro deri vatives undergo epimerization at C-7 and oxetane ring opening, respect ively.