This work describes the formulation of the manifestly ghost-free (spac
etime) light-cone gauge for bosonic string theory with non-trivial spa
cetime metric, antisymmetric tensor, dilaton and tachyon fields. The a
ction is a general two-dimensional sigma model, corresponding to a clo
sed string theory with a second order action in the Polyakov picture.
The spacetime fields must have a symmetry generated by a null, covaria
ntly constant spacetime vector in order for the light-cone gauge to be
accessible. Also, the theory must be Weyl invariant. The conditions f
or Weyl invariance are computed within the light-cone gauge, reproduci
ng the usual beta functions. The calculation of the dilaton beta funct
ion and the critical dimension is somewhat novel in this ghost-free th
eory. Some exactly solvable light-cone theories are discussed.