THE EFFECT OF THE HYPOLIPIDEMIC COMPOUND LIFIBROL ON BILE-FLOW, BILE LIPIDS AND THE LITHOGENIC INDEX OF BILE IN PIGS

Authors
KIRCHGESSNER M SCHLIACK M SPAULDING G EDER K LOSER R SEIBEL K ERHARDT W ASCHERL R
Citation
M. Kirchgessner et al., THE EFFECT OF THE HYPOLIPIDEMIC COMPOUND LIFIBROL ON BILE-FLOW, BILE LIPIDS AND THE LITHOGENIC INDEX OF BILE IN PIGS, Journal of animal physiology and animal nutrition, 71(4-5), 1994, pp. 261-267
Citations number
15
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of animal physiology and animal nutrition → ACNP
ISSN journal
09312439
Volume
71
Issue
4-5
Year of publication
1994
Pages
261 - 267
Database
ISI
SICI code
0931-2439(1994)71:4-5<261:TEOTHC>2.0.ZU;2-4
Abstract
The present study investigated the effect of lifibrol treatment (5 mg/ kg and 10 mg/kg, respectively) on bile flow and bile composition in pi gs. Lifibrol treatment reduced the rate of cholesterol secretion and c holesterol concentration as well as the lithogenic index of bile. The effect of lifibrol on these parameters was dose dependent. In contrast , bile flow, secretion rate and concentration of phospholipids and bil e acids were not influenced by lifibrol treatment. The results indicat e that lifibrol might be a useful agent in prevention gallstone format ion.