ASSESSMENT OF INFLAMMATION BY URINARY TES TS IN GLOMERULONEPHRITIS

Boiden camera tests, chemiluminescence of urinary supernatant, passive hemagglutination tests were used in measuring chemotactic properties of the urine, intensity of free-radical processes, fibronectin urine c oncentrations, respectively, in 31 glomerulonephritis (GN) patients. T he above parameters were closely related to nephritis activity. These were much lower in patients with nephritis remission, than in subjects with nephrotic syndrome or exacerbation of latent nephritis. Chemotac tic activity and intensity of free-radical processes were unrelated to protein urea which, however, correlated with fibronectin concentratio ns (r=0.35, p<0.05). The authors discuss the role of the mediators' va lues in evaluation of local renal inflammation and feasibility of thei r use as criteria of nephritis activity and prognosis.