FUNCTIONAL-ACTIVITY OF PLASMA AND URINE P LASMINOGEN ACTIVATORS IN LUPUS NEPHRITIS PATIENTS

A fibrin plate technique was employed to study functional activity of plasminogen activators in plasma and urine (FAAP, FAAU), activity of a ntiactivator in plasma (AAAP), urokinase urine activity (UUA) in 35 lu pus nephritis (LN) patients. The latter comprise 3 groups by the disea se severity: 22 patients with active LN attended by urinary syndrome ( group 1), 7 patients with LN associated with nephrotic syndrome (group 2), 6 patients with rapidly progressing LN (group 3). Control groups included 5 SLE patients with unaffected kidneys and 25 healthy subject s. FAAP proved. heterogenous both in SLE and healthy subjects. SLE pat ients with progressive LN had diminishing FAAP which was accompanied b y growing AAAP. The latter reached maximal values in groups 2 and 3. U UA declined with LN aggravation. The relation of low FAAP in LN patien ts to affection of vascular endothelium and binding of plasminogen act ivators with the inhibitors to form inactive complexes is considered.