PRONASE IN AMINO-ACID TECHNOLOGY - OPTICAL RESOLUTION OF NONPROTEINOGENIC ALPHA-AMINO-ACIDS

Authors
PUGNIERE M DOMERGUE N CASTRO B PREVIERO A
Citation
M. Pugniere et al., PRONASE IN AMINO-ACID TECHNOLOGY - OPTICAL RESOLUTION OF NONPROTEINOGENIC ALPHA-AMINO-ACIDS, Chirality, 6(6), 1994, pp. 472-478
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
6
Issue
6
Year of publication
1994
Pages
472 - 478
Database
ISI
SICI code
0899-0042(1994)6:6<472:PIAT-O>2.0.ZU;2-H
Abstract
We describe a practical method to produce pure enantiomers of non-prot einogenic alpha-amino acids by pronase-catalyzed hydrolysis of their m ethyl esters. Each of the two pure enantiomers was obtained in high yi eld, while the reaction conditions were optimized with a view to large scale production. Part of this work was devoted to conceiving an anal ytical procedure especially designed to monitor the steric course of e nzymatic reactions. (C) 1994 Wiley-Liss, Inc.