J. Wray et al., COGNITIVE FUNCTION AND BEHAVIORAL STATUS IN PEDIATRIC HEART AND HEART-LUNG TRANSPLANT RECIPIENTS - THE HAREFIELD EXPERIENCE, BMJ. British medical journal, 309(6958), 1994, pp. 837-841
Objective-To assess the psychological impact of cardiac and cardiopulm
onary transplantation on children. Design-Retrospective cross sectiona
l study. Setting-One British centre performing paediatric heart and he
art-lung transplant operations, four cardiac units in London, three Lo
ndon schools, two London health centres, and the dental department of
a London children's hospital. Subjects-65 children who had been given
heart or heart-lung transplants and two reference groups of 52 childre
n who had had other types of cardiac surgery and 45 healthy children.
Main outcome measures-Development, cognition, and behaviour at home an
d at school as assessed by measures with proved validity and reliabili
ty. Results-Developmental and cognitive measures indicated that childr
en given transplants had significantly lower scores on several paramet
ers, particularly in terms of development in children under 41/2 years
of age. Performance on all tests, however, was within the normal rang
e. There were no significant differences in behavioural ratings betwee
n the transplant and reference groups, though problem behaviour at hom
e was more prevalent in the transplant group. Conclusions-Though cogni
tive development may be within the normal range, there are adverse psy
chological effects associated with cardiac and cardiopulmonary transpl
antation. These data indicate the need for a controlled prospective st
udy in which children and their families are seen before and at regula
r intervals after transplantation. Interventions should he-developed t
hat are tailored to the particular needs of this very specialised grou
p of paediatric patients and their families.