INHIBITION OF T-CELL RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION BY ERBSTATIN

Authors
IMOTO M NAKAMURA T TANAKA S UMEZAWA K
Citation
M. Imoto et al., INHIBITION OF T-CELL RECEPTOR-MEDIATED SIGNAL-TRANSDUCTION BY ERBSTATIN, Bioscience, biotechnology, and biochemistry, 58(9), 1994, pp. 1700-1701
Citations number
17
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
58
Issue
9
Year of publication
1994
Pages
1700 - 1701
Database
ISI
SICI code
0916-8451(1994)58:9<1700:IOTRSB>2.0.ZU;2-H
Abstract
Erbstatin, a tyrosine kinase inhibitor, inhibited p59(fyn)- and p56(lc k)-kinases in vitro with IC(50)s of 0.21 and 0.18 mu g/ml, respectivel y. Inositol phosphates formation, enhanced by anti-CD3, was also inhib ited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-in duced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.