SUPPRESSION OF HYDROGEN PEROXIDE-INDUCED CYTOTOXICITY TOWARD CHINESE-HAMSTER LUNG FIBROBLASTS BY DECYLUBIQUINONE, A COENZYME-Q HOMOLOG

Authors
NAKAYAMA T OGISO Y OSAWA T KAWAKISHI S
Citation
T. Nakayama et al., SUPPRESSION OF HYDROGEN PEROXIDE-INDUCED CYTOTOXICITY TOWARD CHINESE-HAMSTER LUNG FIBROBLASTS BY DECYLUBIQUINONE, A COENZYME-Q HOMOLOG, Bioscience, biotechnology, and biochemistry, 58(9), 1994, pp. 1702-1704
Citations number
11
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
58
Issue
9
Year of publication
1994
Pages
1702 - 1704
Database
ISI
SICI code
0916-8451(1994)58:9<1702:SOHPCT>2.0.ZU;2-M
Abstract
The cytotoxicity of hydrogen peroxide (H2O2) toward Chinese hamster V7 9 cells was assessed with a colony-formation assay. Decylubiquinone, a coenzy me Q homolog, suppressed H2O2-induced cytotoxicity. Almost all the incorporated decylubiquinone was detected as decylubiquinol after incubating the cells for 4h. These results suggest that decylubiquino l reduced in the cells acted as an antioxidant against H2O2-induced ox idative cell injury.