NEUROADAPTATION IN CHRONIC CANNABIS-ABUSE - A CLINICAL AND ELECTROENCEPHALOGRAPHIC STUDY

This report is about electroencephalographic changes in a twenty-eight year old patient with longterm heavy cannabis use. He was admitted to our hospital after he had developed a depressive-apathetic syndrome. Two days after the last cannabis-intake, the patient had recovered fro m initial psychopathology and his EEG was completely inconspicious at this day. Some days later however the patient's behavior became increa singly impulsive and unstabile, while his EEG showed a marked disturbe d regulation of vigilance. In the following weeks his impulsiveness be came less and his EEG returned to normal. We suggest that these altera tions may reflect a discontinuation of the initial neuroadaptation of the central nervous system to the drug.