CARCINOID-TUMOR OF THE LUNG AND TYPE-1 MULTIPLE ENDOCRINE NEOPLASIA ASSOCIATED WITH PERSISTENT HYPERCALCEMIA - A CASE-REPORT

The clinical and laboratory data, and histologic, electron microscopic and immunocytochemical findings of a carcinoid tumor of the lung asso ciated with parathyroid hyperplasia and persistent hypercalcemia are d escribed. The carcinoid tumor consists of uniform cuboidal cells with regular round vesicular nuclei and eosinophilic granular cytoplasm. Th e tumor cells were chromogranin and neuron-specific enolase positive. The CAT scan of the abdomen revealed an adrenal mass, 3 cm in diameter , and an enlarged body in the pancreas. Our patient is still suffering from hypercalcemia and renal colic, despite repeated parathyroid glan d removal, and enucleation of the lung mass. Recent parathyroid scinti graphy with Tc revealed an enlarged parathyroid gland. The thoracic CA T scan is normal. We believe that our patient is suffering from multip le endocrine neoplasia type-1 with persistent hypercalcemia due to hyp erparathyroidism.