COAGULATION-FACTOR-XIII IN PLASMA OF PATIENTS WITH BENIGN AND MALIGNANT GYNECOLOGICAL TUMORS

Fibrinogen and factor XIII were measured in sixty-four women with rece ntly detected gynaecological tumours. Twenty-six of these tumours were benign and 32 were malignant: of the last group, nine patients had me tastases. No patient showed clinical signs of bleeding or thrombosis. A reference group consisted of 31 age-matched healthy women. For fibri nogen, no significant deviation between the patient groups and the con trol group was found. The median values of factor XIII were higher in the benign tumour group than in the control group. In patients with a gynaecological tumour and metastases, factor XIII was significantly lo wer than in the non-metastasized malignancy group or in the benign tum our group.