TIME-COURSE OF SEROTONIN IN PLATELETS FROM PATIENTS WITH AFFECTIVE-DISORDERS

Authors
KARAS SI KORNETOV NA MAKAROVA EV SHERINA OL
Citation
Si. Karas et al., TIME-COURSE OF SEROTONIN IN PLATELETS FROM PATIENTS WITH AFFECTIVE-DISORDERS, Bulletin of experimental biology and medicine, 117(3), 1994, pp. 240-242
Citations number
14
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
3
Year of publication
1994
Pages
240 - 242
Database
ISI
SICI code
0007-4888(1994)117:3<240:TOSIPF>2.0.ZU;2-9
Abstract
Temporal variations in platelet levels of serotonin were found to be s ignificantly decreased in patients with endogenous affective disorders , particularly those with the bipolar type of manic-depressive psychos is. The time course of serotonin content in these cells was not affect ed by either the sex or the age of the patients. In vitro incubation w ith Lithium oxybutyrate raised mean platelet serotonin levels and stab ilized their fluctuation in platelets from healthy subjects but not in those from the mental patients.