Nd. Shushakova et Mg. Efimova, CHANGES OF THE LEVEL OF CYTOCHROME-P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE IN RATS WITH HEREDITARY DEGENERATION OF THE RETINA, Bulletin of experimental biology and medicine, 117(3), 1994, pp. 261-264
In animals with hereditary degeneration of the retina the level of cyt
ochrome P-450 in the brain microsomal fraction is found to be higher t
han that in healthy animals. In rats with hereditary degeneration of t
he retina the activity of NADPH-cytochrome P-450 reductase is unchange
d in all tissues examined except for the retina, where it is markedly
higher than in healthy animals on postnatal day 90.