EFFECT OF LONG-TERM LOVASTATIN TREATMENT ON THE NUMBER OF GLUCOCORTICOID RECEPTORS IN PERIPHERAL-BLOOD LYMPHOCYTES

Authors
POZDEEVA EV PETRICHENKO IE AKHMEDZHANOV NM ZHIDKO NI SHAKHOV YA
Citation
Ev. Pozdeeva et al., EFFECT OF LONG-TERM LOVASTATIN TREATMENT ON THE NUMBER OF GLUCOCORTICOID RECEPTORS IN PERIPHERAL-BLOOD LYMPHOCYTES, Bulletin of experimental biology and medicine, 117(3), 1994, pp. 273-276
Citations number
14
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
3
Year of publication
1994
Pages
273 - 276
Database
ISI
SICI code
0007-4888(1994)117:3<273:EOLLTO>2.0.ZU;2-G
Abstract
A reduced number of H-3-dexamethasone-specific binding sites (glucocor ticoid receptors) in lymphocytes was observed after 2 months of lovast atin treatment against the background of a lowered serum level of chol esterol and triglycerides and a reduced rate of cholesterol synthesis in lymphocytes. This phenomenon is considered as an adaptive reaction of the cells to relative cholesterol depletion due to inhibition of it s intracellular synthesis.