REGULATION OF THE ADENYLATE-CYCLASE SYSTEM IN THE LUNGS OF RATS TREATED WITH PLAGUE TOXIN

Authors
CHERKASOVA TD YURKIV VA POKROVSKII VI
Citation
Td. Cherkasova et al., REGULATION OF THE ADENYLATE-CYCLASE SYSTEM IN THE LUNGS OF RATS TREATED WITH PLAGUE TOXIN, Bulletin of experimental biology and medicine, 117(3), 1994, pp. 280-282
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
3
Year of publication
1994
Pages
280 - 282
Database
ISI
SICI code
0007-4888(1994)117:3<280:ROTASI>2.0.ZU;2-A
Abstract
It is demonstrated that the ''murine'' lethal toxin of Yersinia pestis desensitizes the beta-adrenergic receptors coupled to the pulmonary a denylate cyclase system. The degree of adenylate cyclase activation in rat pulmonary membrane preparation by isoproterenol or histamine and the number of beta-adrenergic receptors decrease after a 2-h incubatio n with the toxin.