HLA, ESD, GLOI, C3 AND HP POLYMORPHISMS AND JUVENILE INSULIN-DEPENDENT DIABETES-MELLITUS IN TAMIL-NADU (SOUTH-INDIA)

Fifty juvenile insulin dependent diabetes mellitus (JIDDM) patients of Tamil Nadu (South India) were typed for HLA-A, -B, -C, -DR, and -DQ, ESD, GLOI, C3 and HP polymorphisms. The frequencies of B8, DR3, DR4, D R53 and DQ2 antigens of the HLA system were significantly higher in th e patients than in controls (relative risk, RR = 4.81; 5.14; 3.98; 3.3 6 and 2.53, respectively). However HLA-DR2, -DR5 and -DQ1, observed le ss frequently in the patient group, appear to play a role of protectio n against the disease (RR = 0.32; 0.30 and 0.20 respectively). HLA hap lotype analysis demonstrated very high relative risk associated with t wo hitherto unreported haplotypes namely A3,DR I and Cw3,DR4 (RR = 27. 30 and 20.00, respectively) and also scanty distribution of the haplot ypes A1,B17 and DR2,DQI (RR = 0.39 and 0.36, respectively) in the pati ent group. Among other genetic markers tested, GLOI is informative wit h its phenotype GLOI 2-1 showing positive association with JIDDM (RR = 4.06).