L. Chyczewski et al., INFLUENCE OF BRAIN HYPOXIA ON MEGAKARYOCYTIC EMPERIPOLESIS IN RATS, Folia histochemica et cytobiologica, 32(3), 1994, pp. 187-190
An evaluation of frequency and intensity of the megakaryocytic emperip
olesis in the rat bone marrow after unilateral carotid artery occlusio
n was performed. The results were compared with those obtained in the
group undergoing a blood loss and the group not subjected to surgical
procedures. A significant increase in the frequency of emperipolesis w
as found in the bled rats following a carotid artery cannulation, but
also in animals exposed to the carotid artery occlusion only. In most
cases the cytoplasm of megakaryocytes contained granulocytes and eryth
roblasts. The observed emperipolesis phenomenon is likely to be a resu
lt of brain hypoxia and a secondary neurogenic stimulation of the bone
marrow activity.