EFFECTS OF TICLOPIDINE ON PLATELET ACTIVITY AND OCCLUSION OF ARTERIOVENOUS-FISTULAS IN IPD PATIENTS

It is often assumed that the drug which prevents platelet adhesion or aggregation will also prevent thrombosis.1-3 In patients with chronic renal failure, an arteriovenous (A-V) fistula should be created 2 mont hs prior to initiation of hemodialysis, since there is a fairly high i ncidence of early thrombotic complications. Antiplatelet therapy has n ot become common practice for patients with A-V fistulas. Ticlopidine has been shown to inhibit platelet adhesion, as well as platelet aggre gation induced by various agents.1 For this reason, we evaluated the i nfluence of this drug on platelet function and prevention of thromboti c occlusion of A-V fistulas in the early postoperative period in inter mittent peritoneal dialysis (IPD) patients.