PRENATAL-DIAGNOSIS OF TRISOMY-12 MOSAICISM - PHYSICAL AND DEVELOPMENTAL FOLLOW-UP

Follow-up evaluations were performed on a child at the ages of 2 years 8 months and also at 5 years who had been found on prenatal amniocent esis to be mosaic for trisomy 12. Eight of 36 colonies (22 per cent) w ere trisomy 12 at amniocentesis, with the remaining colonies showing a normal female karyotype. Cord blood, amnion, chorion, placental, and skin fibroblast chromosome studies failed to show any further evidence of a trisomy 12 cell line. At her evaluations, the child had normal p hysical and neurological findings. Psychomotor development was appropr iate for age on screening.