PROSPECTIVE FOLLOW-UP-STUDY OF 55 CHILDREN BORN AFTER SUBAZONAL INSEMINATION AND INTRACYTOPLASMIC SPERM INJECTION

In 163 couples referred for assisted fertilization, pregnancy was esta blished by subzonal insemination (SUZI), intracytoplasmic sperm inject ion (ICSI) or a combination of both techniques, These couples agreed t o participate in a prospective study that included a prenatal diagnosi s and clinical follow-up of the children, No cytogenetic aberrations w ere observed in 43 children tested. In 23 pregnancies occurring after SUZI, 15 women gave birth to 21 children. After replacement of combine d SUZI and ICSI embryos, 10 pregnancies resulted in 8 deliveries with 10 children. Transfer of ICSI embryos led to 130 pregnancies ending in 20 deliveries with 24 children, with many others still ongoing succes sfully. In total, 55 children have been examined: 29 boys and 26 girls . One child from a singleton pregnancy presented multiple congenital m alformations; one twin child presented a quadriparesis. In this observ ational study on a limited number of children, the incidence of major malformations was not different from the incidence in the general popu lation.