SELECTIVE FREE-RADICAL DECHLORINATION OF 1,1-DICHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER INITIATED THERMALLY OR BY UV-LIGHT - A PRACTICAL AND GREEN METHOD FOR ISOFLURANE SYNTHESIS

Authors
RAMIG K QUIROZ F VERNICE GG ROZOV LA
Citation
K. Ramig et al., SELECTIVE FREE-RADICAL DECHLORINATION OF 1,1-DICHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER INITIATED THERMALLY OR BY UV-LIGHT - A PRACTICAL AND GREEN METHOD FOR ISOFLURANE SYNTHESIS, Journal of fluorine chemistry, 80(2), 1996, pp. 101-104
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of fluorine chemistry → ACNP
ISSN journal
00221139
Volume
80
Issue
2
Year of publication
1996
Pages
101 - 104
Database
ISI
SICI code
0022-1139(1996)80:2<101:SFDO1>2.0.ZU;2-B
Abstract
Treatment of 1,1-dichloro-2,2,2-trifluoroethyl difluoromethyl ether (3 ) with 2-propanol followed by either irradiation with UV light or heat ing with radical initiators gives the inhalational anesthetic isoflura ne. Unlike most other common dechlorination methods, monoreduction is the exclusive process and the by-products acetone and HCl are relative ly benign. Some comments about the mechanism of the reduction will be presented, along with solutions to problems encountered during scale-u p.