INTENSIFICATION OF CHRONIC MYELOID-LEUKEM IA THERAPY IN RELATION TO THE PROGNOSTIC FACTORS

A multifactorial computer analysis of current modalities in relevant t reatment performed for 208 patients with chronic myeloid leukemia (CML ) has revealed a close relationship between the set of unfavourable fa ctors upon the diagnosis, choice of treatment and the patients' surviv al. For groups of patients with a standard CML risk it is preferable t o use monotherapy. More intensive treatment (polychemotherapy) is indi cated in the disease progression. The patients at moderate and high CM L risk are recommended to be treated intensively (polychemotherapy, po lychemotherapy + leukocytapheresis, splenectomy) from the start, that is upon CML diagnosis. The above approach promotes longer survival of CML patients.