CHANGES IN THE JOINT MATTER COMPOSITION A ND PROPERTIES IN PATIENTS WITH HEMOPHILIC ARTHROPATHY ON LOCAL INVASIVE THERAPY

An immunological study has been made in 47 hemophiliacs with arthropat hies receiving local invasive therapy. Joint contents were examined in 20 patients with acute hemarthrosis, 10 patients with exudative synov itis and 11 ones with proliferative synovitis. Under the protection of cryoprecipitate (5 U/kg) all the patients underwent joint puncture wi th removal of the contents, lavage of the synovial cavity and intraart icular injection of 50 mg of hydrocortisone, Arthropathy activity prov ed most active in patients with proliferative synovitis. Introduction of local invasive therapy early in hemarthrosis course arrests immune inflammation. Delayed punctures are less effective. Local immunologica l responses, as shown by repeated punctures, noticeably reduced, at pu ncture 3-4 the contents were small, immune complexes and immunoglobuli ns decreased significantly.