EFFICACY OF VERAPAMIL, NIFEDIPINE AND PRO PRANOLOL HYDROCHLORIDE IN CORONARY-DISEASE PATIENTS AT HIGH-RISK OF LETHAL OUTCOME

In a randomized controlled trial 329 postmyocardial infraction patient s with high-grade ventricular extrasystoles were divided into 3 groups . Group 1 of 112 patients received calcium antagonists (verapamil, nef edipine, verapamil + nifedipine), group 2 of 100 patients received pro pranolol hydrochloride, group 3 consisted of 117 controls. The aim of the study was to elucidate the effect of the above drugs on sudden dea th and repeated nonfatal infaraction risk. The mean follow-up duration made up 16+/-0.9, 16.8+/- 1.1, 20.8+/- 1.0 months for groups 1,2 and 3, respectively. 35 patients of the treatment groups turned out unappr eciable because of early discontinuation of chemotherapy. Overall leth ality for the groups 1,2 and 3 reached 0.9%, 4% and 12% of patients, r espectively. Most of lethal outcomes in the controls were sudden. Repe ated nonfatal myocardial infaraction arose less frequently in groups 1 and 2, but the difference was insignificant.