UV BLOOD IRRADIATION IN ACUTE PNEUMONIA - SOME MECHANISMS OF THERAPEUTIC ACTION AND OPTIMIZATION OF INTERVALS BETWEEN THE PROCEDURES

Mechanisms of therapeutic action of UV blood irradiation and optimal i rradiation scheduling were studied in the course of UV-irradiated bloo d transfusions capable of correcting lipid peroxidation (LPO) and anti oxidant system (AOS) in acute pneumonia (AP) patients. Single and mult iple measurements of LPO and AOS parameters (malonic dialdehyde, dieni c conjugates, red cell resistance to peroxide hemolysis, catalase, sup eroxide dismutase, cerulloplasmin, plasma total estrogens, progesteron and testosteron) were made in 10 young males with moderate AP and 20 healthy controls. UV blood irradiation in AP is shown to be pathogenet ically validated. It works via effective stabilization of LPO as a res ult of early adequate stimulation of endogenic AOS. Positive changes w ere also induced in the system of hormonal regulation. It is suggested that hyperestrogenemia plays a compensatory role in AP pathogenesis.