An. Tsoi et al., THEOPHYLLINE SALIVARY AND SERUM CONCENTRA TIONS IN PATIENTS WITH BRONCHOOBSTRUCTIVE SYNDROME AND RELEVANT CORRELATIONS, Terapevticeskij arhiv, 66(8), 1994, pp. 42-44
Theophylline salivary and serum concentrations (T(ser) and T(sal) were
quantified after a single dose administration of theophylline drugs:
euphylline (2.4% solution, 10 ml i.v. jet and 0.15 orally), theo-dur,
retaphil, theopek, theobilong (0.3 g orally). The drugs were given to
patients with bronchoobstructive syndrome. The samples were obtained w
ithin 6 and 24 hours upon administration for euphylline and other drug
s, respectively. T(ser) and T(sal) were determined at high-performance
liquid chromatography. The authors revealed a linear relationship bet
ween T(ser) and T(sal) in different time intervals. The percentage fac
tors and formulas of T(ser) calculation by its T(sal) values have been
estimated.