EXCLUSION OF LINKAGE TO 14Q23-24 IN A FAMILY WITH HOLT-ORAM SYNDROME

Holt-Gram syndrome is an autosomal dominant disorder with congenital h eart defects and skeletal malformations of the upper extremities. A pa tient with a deletion of 14q23-24 and Holt-Gram syndrome has been desc ribed. In this report, however, genetic linkage to the 14q23-24 region is excluded in a multigeneration family with five available individua ls affected with Holt-Gram syndrome. Familial Holt-Gram syndrome might be different from the syndrome with the 14q23-24 deletion.