IMMUNOGENETIC ANALYSIS OF SUCCESSFUL AND REJECTED BONE-MARROW GRAFTS WITHIN ONE FAMILY

We report the case of an Indonesian patient who required urgent bone m arrow transplantation for acute leukaemia and who received successive transplants from two siblings. The first transplant failed while the s econd was successful. There were some uncertainties in serological typ ing due to the presence of cross-reacting HLA-B alleles, lack of pater nal typing and the use of Caucasoid sera for Indonesian patients. Dist inction between the two donors was also difficult. Interestingly, the use of a new DNA technique identified the presence of differences betw een the patient and the first unsuccessful donor but not the second su ccessful donor.